New Day Medspa now offers Letybo, the newest FDA-approved neuromodulator to reach the US market. If you've been asking how long Letybo lasts or searching for Letybo before-and-after examples before booking, this guide covers both directly. Letybo (letibotulinumtoxinA) works the same way Botox does, by temporarily relaxing the muscle that causes frown lines between the brows. Still, it's a distinct product with its own approval history, dosing, and track record. Here's what the research actually shows and what to expect at your appointment in Jacksonville, FL.
What does this article cover?
- What Letybo is and how it compares to Botox and other wrinkle relaxers
- How long does Letybo last, based on FDA labeling and clinical trial data
- What do Letybo before and after results actually look like
- What a Letybo appointment involves at New Day Medspa
Key takeaways
- Letybo received FDA approval in February 2024 specifically for moderate to severe glabellar lines (the "11s" between the brows)
- Results typically last up to 16 weeks (approximately 4 months), with retreatment recommended no more than once every 3 months per FDA labeling.
- Letybo before-and-after data from phase 3 trials showed significant improvements in appearance and patient-reported satisfaction compared with placebo.
- Wrinkle relaxer treatment at New Day Medspa, including Letybo, starts at $8.99 per unit.
What is Letybo?
Letybo is the brand name for letibotulinumtoxinA-wlbg, a purified botulinum toxin type A made by Hugel, a South Korean pharmaceutical company, in partnership with Croma Pharma. It works through the same basic mechanism as Botox, Dysport, Xeomin, Jeuveau, and Daxxify: it blocks the release of acetylcholine at the neuromuscular junction, which temporarily stops the treated muscle from contracting fully. Less muscle movement means the skin above it stays smoother.
What sets Letybo apart is its regulatory history and its narrower initial approval. The FDA approved Letybo in February 2024 specifically for moderate to severe glabellar lines, the vertical frown lines between the eyebrows caused by the corrugator and procerus muscles. Botox, by comparison, is FDA-approved for glabellar lines, forehead lines, and crow's feet. Letybo has been used internationally, particularly in South Korea, for years before its US approval, so the product itself isn't new even though it's new to American patients.
All botulinum toxin products carry an FDA Boxed Warning about the potential for toxin effects to spread beyond the injection site. At cosmetic doses, this is rare, but your provider will review this with you before treatment.
How long does Letybo last?
This is the question most people ask first, and the honest answer is that Letybo's duration is comparable to Botox. Results typically last up to 16 weeks (approximately 4 months), with retreatment recommended no more than once every 3 months per FDA labeling.
A few factors affect exactly how long Letybo lasts for any individual patient:
- Muscle strength. Stronger corrugator and procerus muscles may show earlier return of movement than smaller, weaker muscles.
- Metabolism. A faster metabolism tends to break down the product more quickly.
- Dose. Under-dosing is one of the most common reasons any neuromodulator, including Letybo, wears off faster than expected.
- Treatment history. As with other neuromodulators, repeated Letybo treatment over time may lead to muscle deconditioning, which can make later results last slightly longer for some patients.
Onset is faster than some patients expect. Clinical literature on Letybo describes visible improvement beginning within 2 to 6 days, with full results developing over the following 1 to 2 weeks, a timeline similar to Botox and Dysport.
What do Letybo's before-and-after results look like?
Letybo's before-and-after outcomes are backed by real clinical data, not just marketing claims. A study published in PubMed evaluating letibotulinumtoxinA across phase 3 clinical trials assessed 1,272 enrolled and treated subjects and found that 85.5% had a moderate-to-severe psychological impact from their glabellar lines at baseline. After treatment, subjects reported a mean improvement to week 4 of -33.84 on a validated quality-of-life scale, compared to just -1.37 for the placebo group, a statistically significant difference (p < .001). The same research found that the improvement in psychological burden was strongly correlated with a reduction in glabellar line severity.
In practical terms, Letybo before-and-after photos typically show softened, shallower frown lines at rest and during animation, with the treated area looking more relaxed rather than static or frozen when the correct dose is used. As with any neuromodulator, results build gradually over the days following treatment rather than appearing instantly.
Expert tip: If you're comparing Letybo before-and-after photos online, check the timestamps on the two images. A photo taken on day 3 after treatment looks different from one taken at day 14, since full results take about two weeks to develop. Comparing a "before" photo to a too-early "after" photo can make results look less dramatic than they actually are once the treatment fully settles in.
How does Letybo compare to Botox and other wrinkle relaxers?
All FDA-approved neuromodulators work through the same mechanism, but they differ in formulation, approved uses, and molecular structure. Here's how Letybo stacks up:
Letybo is currently FDA-approved only for glabellar lines. Unlike Botox, Xeomin, and Jeuveau, Letybo is not currently approved for forehead lines or crow's feet.
Units across these products are not interchangeable. A unit of Letybo is not equivalent to a unit of Botox or Dysport because product-specific assays measure potency. Your provider will determine the right dose of Letybo independently, rather than by converting a Botox dose you may have had previously.
Curious whether Letybo is the right fit for you? Book a complimentary consultation at New Day Medspa in Jacksonville, FL. Licensed ARNPs and PAs will assess your glabellar muscle activity and walk you through whether Letybo, Botox, or another wrinkle relaxer is right for your goals.
What does a Letybo appointment involve?
A Letybo appointment follows the same basic process as any wrinkle relaxer visit. Your provider reviews your medical history and current medications, assesses the strength and pattern of your glabellar muscles at rest and while frowning, and confirms the treatment plan and dose before injecting. The FDA-labeled total dose for Letybo in glabellar lines is 20 units, divided into five injections of 4 units each, two in each corrugator muscle and one in the procerus muscle at the center of the brow.
The injections themselves take just a few minutes. Most patients describe a brief pinch at each site. There's no downtime. Standard aftercare applies: avoid lying down for 4 hours, skip intense exercise for 24 hours, and don't rub or massage the treated area for the rest of the day.
What does Letybo cost at New Day Medspa?
Wrinkle relaxer treatment at New Day Medspa, including Letybo, starts at $8.99 per unit. Since the standard glabellar dose is 20 units, a typical Letybo treatment starts around $180, though your provider will confirm the exact dose and cost based on your anatomy at the consultation. If you're also treating other areas in the same visit, such as the forehead or crow's feet, your provider can discuss which product makes sense for each area, since Letybo's current FDA approval specifically covers glabellar lines.
New Day Medspa offers financing through Cherry, PatientFi, Afterpay, and Klarna for patients who want to spread the cost of treatment over monthly payments.
About New Day Medspa
New Day Medspa is a medically guided aesthetic practice with a location in Jacksonville, FL. All wrinkle relaxer treatments, including Letybo, Botox, and other FDA-approved neuromodulators, are performed by licensed ARNPs and PAs with specialized training in facial anatomy. Wrinkle relaxer treatment starts at $8.99 per unit, and every appointment begins with a complimentary consultation to determine the right product and dose for your goals.
Suggested articles
Botox Injections in Jacksonville, FL: Cost, Results, and Safety Tips - A broader look at wrinkle relaxer treatment in Jacksonville, including cost, result timelines, and how to choose a qualified provider, with useful context specifically for Letybo.
How Much Is Botox in Jacksonville, FL? A 2026 Price Breakdown - Covers per-unit pricing structure and what affects cost, which applies to Letybo pricing as well.
What Is Botox Made Of? Understanding the Science Behind the Treatment - Explains the underlying formulation and mechanism shared across botulinum toxin products, including how Letybo compares at the ingredient level.
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